# Best answer: What is likely to occur if end diastolic volume remains the same but end systolic volume doubles?

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## What is the relationship between end diastolic volume and the magnitude of stroke volume?

Calculation. Its value is obtained by subtracting end-systolic volume (ESV) from end-diastolic volume (EDV) for a given ventricle. In a healthy 70-kg man, ESV is approximately 50 mL and EDV is approximately 120mL, giving a difference of 70 mL for the stroke volume.

## What effect will increasing the end diastolic volume have on the cardiac output?

An increase in EDV increases the preload on the heart and, through the Frank-Starling mechanism of the heart, increases the amount of blood ejected from the ventricle during systole (stroke volume).

## What will happen if the stroke volume in the right ventricle is greater than the stroke volume in the left ventricle?

During cardiovascular stress, if right ventricular (RV) exceeds left ventricular (LV) stroke volume, then a large volume of blood is displaced into the pulmonary circulation that may precipitate pulmonary edema.

## What happens when end diastolic pressure increases?

Impaired left ventricular function leads to increased left ventricular end-diastolic pressure (LVEDP) and reduced stroke volume. Increased LVEDP causes increased pulmonary capillary hydrostatic pressure, which results in the increased filtration of protein-poor fluid into the pulmonary interstitium (Equation 1-12).

## When does end-diastolic volume occur?

End-diastolic volume refers to the quantity of blood in the left or right ventricle at the end of diastole, just before systole starts. The heart consists of four chambers: two atria and two ventricles.

## What determines end-diastolic volume?

The end-diastolic volume (preload) is a measure of the filling of the ventricle, determined by ventricular distensibility and the ventricular filling pressure.

## Why does increased end-diastolic volume increase contractility?

Briefly, an increase in venous return to the heart increases the filled volume (EDV) of the ventricle, which stretches the muscle fibers thereby increasing their preload. This leads to an increase in the force of ventricular contraction and enables the heart to eject the additional blood that was returned to it.

## What factors affect EDV?

Stroke Volume is the difference between end diastolic volume (EDV) and end systolic volume (ESV). ESV can be affected by 4 factors; preload, afterload, contractility, and Heart rate, and EDV also depends on 3 factors; venous return, Heart rate, and compliance.

## Does increased end-diastolic volume increase ejection fraction?

Because stroke volume decreases and end-diastolic volume increases, there is a substantial reduction in ejection fraction (EF).

## What is normal end diastolic pressure?

The volume of blood in the left ventricle at the end of ventricular filling is called the end-diastolic volume (EDV), which is about 120 mL in the adult human. The corresponding pressure, the end-diastolic pressure (EDP), is about 4–7 mmHg.

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## How does a decrease in venous return affect end diastolic volume?

Vena cava occlusion decreases venous return to the heart, thereby causing a progressive fall in end-diastolic volume (preload) over several beats. As preload progressively decreases, the PV loop moves to the left and gets smaller.

## How does stroke volume affect blood pressure?

An increase in right ventricular stroke volume increases pulmonary venous blood flow to the left ventricular, thereby increasing left ventricular preload and stroke volume. An increase in stroke volume then increases cardiac output and arterial blood pressure.

## What causes increased end-systolic volume?

End-systolic volume depends on two factors: contractility and afterload. Contractility describes the forcefulness of the heart’s contraction. Increasing contractility reduces end-systolic volume, which results in a greater stroke volume and thus greater cardiac output.

## What is systolic and diastolic pressure?

Blood pressure is measured using two numbers: The first number, called systolic blood pressure, measures the pressure in your arteries when your heart beats. The second number, called diastolic blood pressure, measures the pressure in your arteries when your heart rests between beats.

## Is end-systolic volume the same as afterload?

Afterload is increased when aortic pressure and systemic vascular resistance are increased, by aortic valve stenosis, and by ventricular dilation. When afterload increases, there is an increase in end-systolic volume and a decrease in stroke volume.